Volume :
3
Issue :
4
Abstract :
Alloxan (A) is a highly toxic especially the liver and pancreas. The present study was designed to evaluate the antioxidant effect of flavonoids on alloxan-induced hepatic dysfunction, elevation of gamma glutamyl transpeptidase (GGT) and oxidative stress in rats. Adult male Wister rats were administered by alloxan monohydrate (120 mg/kg bw i.p route) This study revealed significant liver enzyme Gamma glutamyl transpeptidase(GGT) elevation, lipid peroxidation and a decline in antioxidant enzyme activities in the liver of alloxan-treated rats compared to control animals. flavonoids significantly increased (p < 0.05) antioxidant enzymatic activities (Glutathione, MDA), and reduced elevated blood glucose and GGT levels compared to those given alloxan alone. Thus, the oral administration of flavonoids, significantly (p < 0.05) improves alloxan-induced liver dysfunction and stress oxidant in rats. The present results shown that Flavonoids (quercetin, chrysin and hesperidin) has an antihyperglycaemic effect and consequently may alleviate elevation of GGT and oxidative stree in associated with alloxan-induced diabetes mellitus in rats.