Volume :
2
Issue :
2
Abstract :
Antifungal drug, Ketoconazole was encapsulated in liposomes for topical application. The main objective of the present work was to formulate and characterized a liposomal carrier containing ketoconazole and to investigate the drug delivery of ketoconazole which is an antifungal drug having limited transdermal permeation. The liposomes were characterized for size, entrapment efficiency, skin penetration, vesicle skin interaction and stability study. The partical size was determined by photo correlation spectroscopy which was found to be 222±15nmfor empty vesicle and 264±12nmfor drug loaded vesicle, encapsulation efficiency was determined by dialysis technique (40.12±1.9%).Skin penetration can be determined by using confocal laser scanning microscopy (CLSM) (168μm). Vesicle skin interaction study can be determined by using optical microscope, stability of ketoconazole loaded liposomes can be determined by assessing the size and structure of vesicle over time. Our results indicate that ketoconazole loaded liposomal carrier could be better choice for the treatment of number of dermal infections.