Abstract :
Objective: The aim of this work includes the synthesis of nitrone compounds derived from glyoxal by a condensation reaction with substituted arylhydroxylamines and evaluation of their antimicrobial efficacy. Materials and Methods: The present work concerned the synthesis of arylhydroxylamine derivatives and subsequently reacted with glyoxal (40%) to synthesize the nitrone compounds. Results: The synthesized nitrones in our study, their structures identified with Fourier-transform infrared and 1H-Nuclear magnetic resonance spectroscopies in addition to elemental analysis (C.H.N.). The results support the structures of nitrone compounds. Conclusion: Synthesized nitrones obtained in high purity and an excellent yield. The synthesized nitrones investigated for evaluation of their antimicrobial efficacy against Gram-positive (Staphylococcus aureus, ATCC 25923) and Gram-negative (Escherichia coli, ATCC 25922) bacteria and fungus (Aspergillus niger and Aspergillus flavus). The study proved that the synthesized nitrones exhibited significant antimicrobial activity.
Keyword :
Antimicrobial activity, condensation reactions, glyoxal, nitrones