Abstract :
Maternal hypothyroidism is known to be associated with adverse
perinatal outcomes. This study was done to evaluate the normal
reference range of TSH in pregnant women. 483 pregnant women on
their first visit to Obstetrics OPD in Era's Lucknow Medical College
and hospital were tested for TSH and TPO antibody using ELISA
method. 25 out of 483 were positive for TPO Antibody. Of the
remaining 458 patients, 142 were in first trimester, 222 were in second
trimester and 94 were in third trimester. The TSH values ranged from
0.043 mIU/L to 10.1 mIU/L (mean = 2.34 mIU/L). The reference range
of TSH values in all the trimesters are, 0.35 to 5.82(1st trimester), 0.28 to 5.82(2nd trimester) and 0.11 to 6.8(3rd
trimester). The reference range of TSH values among the normal pregnant women of Lucknow and its surrounding
areas were found to be higher than those recommended by the test kit.
Keyword :
TSH, TPO, Hypothyroidism