Abstract :
We have tried to synthesize a series of 5 derivatives of Pyrimidine. Synthesis was carried out according to
reactions shown in Reaction Scheme. At first, 4th position of 2,4 dichloropyrimidne was substituted by Anthranilic
acid to form Synthesis of 2-(2- chloropyrimidin-4-ylamino)benzoic acid 1[C]. 5amino-1,3,4-thiadiazole 2[B] was
prepared using Synthesis of 2-(2-chloropyrimidin-4ylamino)benzoic acid 1[C] and Thiosemicarbazide as starting
material. Further confirmation was carried out by IR which showed the presence of amino (-NH2) band ~3422.80
cm-1, 1H NMR spectra which revealed all the corresponding peaks at δ=4-8 ppm for aromatic protons. MASS
spectrum showed M+1 peak at 305.4
Various Substituted Pyrimidine derivatives (3[B-1]-3[B-5]) were prepared from substituted aniline(3[A-1]-3[A-5])
by reacting with5-[2-((2-chloropyrimidine- 4yl)amino)phenyl)-1,3,4-thiadiazol-2-amine 2[B] .The reaction was
monitored by Thin-layer chromatography using suitable mobile phase such as Chloroform: Methanol (9:1); nhaxane:ethyl
acetate (5:5). The Rf values were compared and found that they were different from each others. The
melting point of the derivatives was determined.
Spectral study of all the derivatives of substituted Pyrimidine derivatives was carried out using IR, 1H NMR, and
MASS which leads us to believe that all the derivatives has been properly synthesized.
Key Words: Anticancer activity, synthesis, characterisation.
Keyword :
Anticancer activity, synthesis, characterisation.