Abstract :
The synthesis of a new series of 2-(cyclic amine)-1, 3-benzothiazole derivatives were synthesized in satisfactory
yield and evaluated for their anti-microbial activities. 2-(cyclic amine)-1, 3-benzothiazoles were synthesized by
treating 2-chloro benzothiazole with various cyclic amines. Purity of all the compounds has been checked on thin
layer chromatographic plate technique. The structures of these newly synthesized compounds were characterized by
elemental analysis and spectral data like IR, 1HNMR, 13CNMR and mass spectroscopy. All the synthesized
compounds have been screened for their anti-microbial activity (MIC) in vitro by broth dilution method with two
Gram-positive bacteria, two Gram-negative bacteria and two fungal stains. The compounds exhibit significant
antibacterial activity, when compared with that of standard drug Streptomycin. Also show moderate degree of
antifungal activity when compared with a standard drug Amphotericin-B.
Keyword :
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-CYCLIC AMINE BENZOTHIAZOLE DERIVATIVES