Abstract :
Introduction: This study investigates the functional roles and predicted interactions of the putative beta-lactamase STY4057 in using STRING database analysis. is a pathogenic bacterium responsible for typhoid fever, presenting significant public health challenges.
Methods: We identified several key functional partners of STY4057 by exploring various interaction criteria, including gene fusion, co-occurrence, co-expression, and experimental data through STRING database analysis.
Results: The analysis revealed interactions with regulatory proteins, metabolic enzymes, and proteins involved in adhesion and biofilm formation. High-confidence interactions with STY4058 (a regulatory protein) and apeE (an outer membrane esterase) suggest significant roles in transcriptional regulation and lipid metabolism.
Discussion: The findings underscore the potential contribution of STY4057 to antibiotic resistance and pathogenicity in . Interactions with regulatory proteins like STY4058 may influence beta-lactamase expression, while interactions with metabolic enzymes like apeE could affect membrane permeability and antibiotic influx, providing insights into s survival and resistance mechanisms.
Conclusion : This study lays the groundwork for future experimental validation and therapeutic target development, offering insights into s survival and resistance capabilities. Further research is needed to validate these interactions and explore their potential as therapeutic targets.
Keyword :
Beta-lactamase, Salmonella typhi, STRING database, Antibiotic resistance