Abstract :
Background: Hypertensive disorders in pregnancy are a spectrum of disorders ranging from gestational hypertension, pre-eclampsia to eclampsia and chronic hypertension superimposed by pre-eclampsia. With an incidence of 7-15% complicating pregnancies, several theories have been stated to define the pathogenesis. Inflammation per se is also found to have its part in the pathogenesis of hypertension.
Objective: To evaluate and compare the inflammatory mediators namely the leukocyte count, platelet count, absolute neutrophil count, absolute lymphocyte count, neutrophil lymphocyte ratio and platelet lymphocyte ratio among the hypertensive disorders in pregnancy.
Materials and Methods: This is a retrospective study done at a tertiary care hospital including all women admitted with hypertension in pregnancy from 26th April 2016 to 31 March 2019. Patients with singleton pregnancy with hypertension were included and those with prelabour rupture of membranes or concomitant infection were excluded. Patients were divided into four groups, chronic hypertension, and gestational hypertension, non-severe and severe preeclampsia. The total and differential leukocyte counts at admission were accessed from the medical records and statistical analysis was done.
Results: Out of 4860 deliveries, 294 patients were diagnosed with hypertensive disorders (6.04%). Of the 294, those belonging to chronic hypertension, gestational hypertension, non-severe and severe preeclampsia were 43 (14.6%), 128(43.5%), 52(17.7%) and 71(24.1%) respectively. A p value of < 0>
Keyword :
Hypertension, Total leukocyte count, Pregnancy, Preeclampsia