Abstract :
Introduction: Non Alcoholic Fatty Liver Disease (NAFLD) is the common chronic liver disorder
worldwide. Postmenopausal state is associated with development of features of meta bolic syndrome and
NAFLD is common in women after their menopause. NAFLD is the one of the manifestation of metabolic
syndrome, which in turn is associated with increased serum uric acid levels.
Aim and Objectives: To estimate serum uric acid levels in Postmenopausal women with NAFLD and
compare it with that of healthy Postmenopausal women and to correlate Waist circumference and BMI
with Sr. Uric acid levels
Materials and Methods: 50 Postmenopausal women with NAFLD in the age group of 45-65 years and 50
age matched healthy Postmenopausal women from the Department of Medical Gastroenterology, RGGH,
-Chennai-3 participated in the study. After obtaining informed consent blood samples were collected for
determining serum uric acid levels using spectrophotometric method.
Results: All the data obtained were analyzed by unpaired t test in SPSS Software. Pearson’s correlation
coefficient was used to determine the correlation between uric acid levels and BMI & Waist circumference
(WC). p value < 0>
acid levels are significantly increased in NAFLD groups than the control groups and serum uric acid levels
showed a positive correlation with BMI & WC.
Conclusion: It may be concluded from the results of the study that uric acid might be involved in the
etiopathogenesis of NAFLD. Hyperuricemia may be the reason for increased cardiovascular adverse effects
in subjects with NAFLD.
Keyword :
NAFLD, Postmenopausal women, Serum Uric acid, BMI, Waist circumference.