Abstract :
Postpartum hemorrhage accounts for > 25% of deaths, an effective treatment for postpartum hemorrhage (PPH) would contribute importantly to the Millennium Development Goal of decreasing maternal mortality.
Objective: To observe whether the antifibrinolytic agent, tranexamic acid reduces maternal mortality, need of hysterectomy in women with diagnosed postpartum hemorrhage and to evaluate adverse drug reaction of tranexamic acid.
Materials and Method: This study was conducted at Department of OBG, Karnataka Institute of Medical Sciences(KIMS) Hubli during May 2010 to April 2011. Hundreds women who has been diagnosed PPH were included in the study. Patients were allocated into two groups:
Control group (fifty case) and Study group (fifty case). To collect and quantify amount of collected blood, BRASS-V˶ drape was used. Numbers and cause of maternal mortality was evaluated. Surgical intervention or hysterectomy required for failed medical management, and maternal side effects caused by tranexamic acid were noted.
Results: Both groups are comparable with regards to, age, parity distribution, type of delivery, causes of PPH (p-value> 0.05). Mean blood loss in control group was 744±102ml while that in tranexamic acid group was 626±113ml this difference between the two groups was highly significant (p value
Keyword :
Hysterectomy, Maternal mortality, BRASS-V˶ drape, Tranexamic acid, Blood loss