Abstract :
Aims and Objectives: To diagnose and grade cases of breast cancer and evaluate their relationship to E-cadherin expression and to evaluate the role of E-Cadherin as a diagnostic and prognostic biomarker in Breast Cancer.
Material and Methods: 234 patients presenting with signs and symptoms of breast lesions were studied after a detailed history and thorough examination. Mastectomy and lumpectomy were processed for routine histopathology and immunostains for ER, PR, HER2/ NEU and E-cadherin and diagnosed and typed according to WHO classification and grading of malignant cases was done as per Modified Scarff-Bloom-Richardson grading scheme.
Results: Fibroadenoma was the most frequently diagnosed benign lesion, 60 cases (55.6%). All the benign cases showed strong and homogenous membranous positivity with intensity score of 4 . Majority of fibroadenoma cases, 8 (40.0%) showed proportion score 3 . Infiltrating ductal carcinoma (not otherwise specified) was the most frequently diagnosed malignant lesion, comprising 67 cases (53.2%), followed by residual/recurrent ductal carcinoma, in 31 cases (24.6%). Most of the Grade 1 IDC showed 3 proportion score, with gradually decreasing score in higher grades. Relationship between grade and E-cadherin score showed a p value of 0.0059, which was statistically significant. All the 6 cases (100%) of infiltrating lobular carcinoma were negative for E-cadherin. Medullary carcinoma showed 1 case each of weak 1 proportion score staining and 2 Intensity score in
Keyword :
Breast Carcinoma, Histopathology, Immunohistochemistry