Abstract :
A total of twelve pyrazolone nucleus-based derivatives (PA1-PA6 & PC1-PC6) were synthesized by a condensation of 4-acyl-5-pyrazolones with aromatic amines, and the aromatic aldehydes added to the parent moiety. All the synthesized carried out their insilico study as well as screened for their cytotoxicity activity. Among all the insilico score of the twelve compounds, the two (PA2 & PC3) were screened with the DLA cells to find out the cytotoxicity. They have shown a moderate activity at the concentration of 150 μg/ml due to the presence of electron with drawing groups 2, 4-dinitro and nitro moieties.
Keyword :
Pyrazolone, Schiff base, Benzylidene, Anticancer activity, Molecular Docking