Abstract :
A series of twelve biologically active pyrazolone derivatives (PA1-PA6 & PC1-PC6) were synthesized by a condensation of 4-acyl-5-pyrazolones with aromatic amines, and the aromatic aldehydes added to the parent moiety. All the newly synthesized compounds were characterized by means of their FTIR, 1H-NMR, MASS spectral data. All the compounds were tested for their antibacterial and antifungal activities by the agar well diffusion method. The Schiff base containing pyarazolones were produced significant activity in the antimicrobial properties against both gram positive and gram-negative bacterial strains at a 100 μg/ml concentration against standard Gentamycin (100 μg/ml).
Keyword :
Pyrazolone, Schiff base, Benzylidene, Antibacterial activity, Antifungal activity.