Abstract :
Background: Extended Spectrum Beta Lactamase (ESBL) are a variant of β-lactamase enzymes that open the β- lactam ring thus inactivating the antibiotic and conferring resistance.
Objective: To determine the prevalence of ESBL producing Gram Negative Bacilli isolated from various clinical specimens and to study their antibiotic susceptibility patterns.
Methodology: A cross sectional study was carried out at the Department of Microbiology, GMERS Medical College, Valsad for a period of 2 months. The antibiotic susceptibility patterns were tested using the Kirby- Bauer disc diffusion method following CLSI guidelines.
Results: 221 specimens were examined. Out of which 39 (18%) were Gram positive isolates, 63(28%) were Gram negative isolates and the rest 119 (54%) were no growth. Out of the 63 Gram Negative, 30(48%) were ESBL positive while the rest 33 (52%) were ESBL negative.
Conclusion: Prevalence of ESBL in Gram negative bacilli was 55% and thereby it sends a signal among the medical fraternity for the rational use of antibiotics.
Keyword :
Antibiotic susceptibility testing, Bacterial resistance, Extended Spectrum Beta Lactamase, Gram Negative Bacilli