Article type :
Review Article
Author :
Kanchan K Mishra, Pooja Desai, Manish Khanna, Sayesha Malhotra, Kanchan K Mishra, Pooja Desai, Manish Khanna, Sayesha Malhotra, Kanchan K Mishra, Pooja Desai, Manish Khanna, Sayesha Malhotra
Volume :
11
Issue :
2
Abstract :
Platelet-Rich Plasma (PRP) has emerged as a valuable tool in regenerative medicine due to its high concentration of autologous growth factors and cytokines that promote healing and tissue regeneration. Effective clinical application of PRP necessitates platelet activation, traditionally achieved through agents such as thrombin, calcium chloride, and collagen. However, these methods present limitations including short-lived bioactivity, potential immunogenicity, and regulatory challenges. This review highlights photoactivation a novel, non-chemical activation technique using polychromatic light as a safe, effective, and legally favorable alternative. Photoactivated PRP (PA-PRP) not only triggers sustained growth factor release and ATP synthesis but also enhances platelet activation, tissue repair, and patient outcomes, particularly in musculoskeletal disorders. Supported by recent in vitro and in vivo studies, photoactivation facilitates prolonged bioactivity and cellular responses without adverse effects, positioning PA-PRP as a promising advancement in orthobiologic therapies. Further clinical validation and protocol standardization are warranted to optimize its therapeutic potential.
Keyword :
Photo activated PRP (PA-PRP), Platelet-rich plasma, Regenerative medicine, Growth factor release, Musculoskeletal disorders.