Abstract :
Natural polymers are one of the important ingredients because of their non-toxicity, biocompatibility, and biodegradability have made them attractive options for creating buccal drug delivery systems. In recent years, buccal drug delivery systems have drawn a lot of attention because they can administer drugs in a regulated and targeted manner, by avoiding the first-pass metabolism and lead to increasing bioavailability. Natural polymers are used in the preparation of in buccal drug delivery systems which have benefits in recent developments are the main topics of this review paper. The main topic focus on this review is mechanism of buccal absorption, formulation parameters especially natural polymers, recents developments along with the future aspects.
Keyword :
Buccal drug delivery, Natural polymers, Chitosan, Alginate, Controlled release, Nanotechnology