Abstract :
Aims: Herpes Simplex Encephalitis (HSE) is a leading cause of acquired cognitive disability. We aimed to describe cognitive sequelae of HSE in relation to clinical variables during hospitalization.
Methods: Consecutive cases of encephalitis with a discharge diagnosis of HSE from January 2010 to December2016 were reviewed to collect the clinical details. Glasgow-Outcome-Score (GOS), Barthel-Index (BI), Seizure-Score (Engel-Score, ES) at the time of discharge, first follow-up and final follow-up were noted. A detailed neuropsychological evaluation was done at last follow-up in survivors and these scores were compared to clinical variables during hospitalization. c2 test, Fisher’s exact test and ANOVA were used for analysis.
Results: There were 30 patients (11males) at a median age of 31.5years. Cerebro-spinal-fluid was abnormal in 82.8%, electroencephalogram in 96.7% and Magnetic Resonance Imaging (MRI) in 80% patients. All were treated with acyclovir and 80% had intensive-care-unit stay. Mortality was 26.7% and it correlated with glasgow coma score
Keyword :
Encephalitis, Herpes, Outcome, Cognitive outcome, Neuropsychology.