Abstract :
Leptomeningeal malignant melanoma is a rare disease in which tumor spreads to meninges surrounding brain and spinal cord. Here, we discuss a case of a47 year male who presented with complain of forgetfullness, difficulty in walking, urinary incontinence, drowsiness, unable to speak and with seizures. A CT brain showed hyperdense area and significant perilesional edema in right temporo-parital region which caused a mass effect. Subdural haemorrhage was noted in right parietal region with periventricular hypo density. For that, patient was operated for right side VP shunt and right frontotemporoparietal craniotomy with excision of right temporal space occupying lesion. HPE showed tumor to be composed of neoplastic cells arranged in sheets, nest and peritheliomatous pattern. Cells were epitheliod to spindly in nature. Mitosis were (>20/10 HPF). Cytoplasm of neoplastic cells showed melanin pigment.
Keyword :
Malignant melanoma, Leptomeningeal melanomatosis, Melanocytes