Author :
Vijaya Jyothi M *, A Sudheer, E Bhargav, Ravi Prasad Rao, C Naresh babu , P Vasima Nazneen, B Pradeep Kumar, S Salamma
Volume :
5
Issue :
04
Abstract :
Caralluma adscendens var. attenuata is a succulent plant grows in tropical areas. It has been reported for the
presence of phenolics, flavanoids, tannins etc., which are responsible for antioxidant activity and hepatoprotection.
Several biological activities like anti diabetic, anti-inflammatory and anti-ulcerogenic were also reported. The
present study was aimed to evaluate invitro antioxidant property as the prime step to carryout invivo antioxidant
and hepatoprotective activity of methanolic stem extract of this plant. In vitro antioxidant activity was evaluated by
determination of total phenolics, flavonoids content, reductive ability and free radical scavenging activity assays. In
vivo studies were performed against ethanol induced liver toxicity in rats using Silymarin as standard. In this study
serum catalase, superoxide dismutase, reduced glutathione levels were quantified. The results obtained by this study
revealed that the concentration of the liver protecting enzymes was not affected by ethanol when animals were
coadministerd with plant extract. Rats which were pretreated with methanolic extract of Caralluma adscendens var.
attenuata inhibited the stimulated serum levels of serum glutamate pyruvate transaminase (SGPT), serum glutamate
oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP) and total bilirubin when compared with silymarin.
The research findings reveal that Caralluma adscendens var. Attenuata has significant antioxidant and
hepatoprotective activities.
Keywords: Alcoholism; Hepatotoxicity; Caralluma adscendens var. Attenuata; Antioxidants; silymarin;
Hepatoprotection.
Keyword :
Alcoholism; Hepatotoxicity; Caralluma adscendens var. Attenuata; Antioxidants; silymarin; Hepatoprotection.