Hypothermia therapy in neonatal hypoxic-ischemic encephalopathy: Current perspectives, combination therapy and future directions


Article PDF :

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Article type :

Review Article

Author :

Moaaz Abo Zeed*, Maher Mohamad Najm, Arwa Ajaj, Mohamad Ahmad Ajaj

Volume :

3

Issue :

3

Abstract :

Hypoxic-ischemic encephalopathy (HIE) in neonates, resulting from oxygen deprivation during birth, is a significant cause of death and long-term disabilities. Therapeutic hypothermia has emerged as a pivotal intervention for improving neurological outcomes in infants with HIE. This review aims to summarize current practices, outcomes, and challenges of hypothermia therapy in neonatal HIE, and adjuvant therapies, along with future directions in this evolving field. 

Keyword :

Therapeutic hypothermia, Hypoxic­ischemic encephalopathy, Cooling, Neonatal neuroprotection