Article PDF :

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Article type :

Original Article

Author :

Sana mubeen, Ghulam Razaque, Noman ul haq, Nisar ahmed, G. Mustafa Shahwani, Zarmeena khan, Aqeel Nasim, M. Zeeshan Danish

Volume :

5

Issue :

04

Abstract :

Among the all sophisticated drug deliveries oral drug delivery is known as safest and most convenient rout of administration. DDS are formulated for rapid release, for CDD (Controlled Drug delivery and release) and for targeted drug delivery. Controlled delivery system is the system which deliver the active ingredient at a predetermined rate and time for the local or systemic effect for a definite period of time. Formulation and development of CR made possible by the polymers i.e is synthetic polymers and natural polymers. Eudragit is an Synthetic amorphous polymer, which is non absorbable, non-biodegradable, and non-toxic polymers. Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug considered to be a second generation flouroquinolone.(12) (13) ofloxacin is approved for the treatment of bacterial infection like chronic bronchitis, community acquired pneumonia, acute pelvic inflammatory disease complicated urinary tract infection. In this study CR drug formulated of Ofloxacin by adding Xanthan Gum and Eudragit RL100 polymers with direct compression method. Pre-formulation studies were conducted which all were according to the standards. Three different drug and polymers ratios were incorporated of two different polymers i.e. 10.3, 10.4, 10.5. Invitro dissolution studies were also conducted, the %age release was enhanced in all formulation. The formulation 10.3 in both formulations enhanced the release rate more than the other formulations. These polymers can also be used in other drug preparations and also suitable for development of CR formulations which may extended the drug release.