Abstract :
The present investigation is concerned with development and evaluation of Sustained release matrix tablets
containing Naproxen using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC K100M & HPMC
K4M).Preformulation study was done initially which include characterization of polymers, drug identification, FTIR
compatibility and result directed for the further course of formulation. The tablets were prepared by direct
compression method and evaluation done. Tablets were compressed by tablet compression machine (Karnavati
Rimek Mini press1)and evaluated with different parameters like diameter, thickness, average weight, hardness,
friability, drug content, kinetic release data. Matrix tablets were compressed without any problem and do not
require any change in ratio of excipients in formulation. Results of the present study demonstrated that combination
of both polymers and insoluble filler could be successfully employed for formulating sustained release matrix tablets
of naproxen. All the formulations containing drug, polymer and DCP as filler sustained the drug release for 24 h.
The drug release rate was slower with the tablet containing combination of HPMC K100M and EC polymers
compared to with that of combination of two hydrophilic polymers (HPMC-K100M and HPMC-K4M). Wet
granulation method was used and found to extend the drug release for 24 h. Hence sustained release drug delivery
system of Naproxen is a promising approach as it can lead to decrease in the frequency of administration and
ultimately lead to better patient compliance.
Keywords: Sustained release drug delivery system, Naproxen, invitro drug release, Direct compression method, Di
calcium phosphate (DCP)
Keyword :
Sustained release drug delivery system, Naproxen, invitro drug release, Direct compression method, Di calcium phosphate (DCP)