Abstract :
Cefadroxil was formulated as mucoadhesive tablets to improve its bioavailability. Xanthan Gum, Guar Gum ,
Chitosan and Acritamer 940 were selected as polymers. Various formulations were prepared by using these
polymers alone Ex vivo permeation study of Cefadroxil drug solution through the porcine mucosa was performed
using franz diffusion cell and the flux value was found to be 400.51 µg.hr-1cm-2, 0.410 cm/hr. The pre-compression
blend of Cefadroxil mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped
density, carr’s index and hausner’s ratio and all the results indicated that the blend was having good flow nature
and better compression properties. The swelling studies were performed for the formulations which were shown
desired drug release. Peak detachment force (N) and work of adhesion were calculated and they were found to be
good. F5 formulation was showing 94.9% drug release in 8 hrs and following Korsmeyer peppas mechanism with
regression value of 0.993. F5 formulation was showing maximum flux value of 382.445 (µg.hrs-1cm-2) and
permeability coefficient value was 0.422 (cm/hrs). So based on the results F5 was found to be an optimised formula
and concluded that Cefadroxil can used as mucoadhesive tablets.
Keywords: Mucoadhesive tablets, Cefadroxil, Bioadhesive polymers, Flux, Permeability coefficient.
Keyword :
Mucoadhesive tablets, Cefadroxil, Bioadhesive polymers, Flux, Permeability coefficient.