Fever with rash; Role of an untold history in clinching the diagnosis


Article PDF :

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Article type :

Case Report

Author :

Kamath PR, Bhat RS, Patel PV, Cholakundan AB

Volume :

2

Issue :

4

Abstract :

Dapsone is a potent antimicrobial and anti-inflammatory compound, which is mainly used in the treatment of leprosy, neutrophilic dermatoses and a variety of blistering skin diseases. It is known to cause a severe adverse drug reaction presenting with fever, rash and multiorgan involvement known as Dapsone Hypersensitivity Syndrome (DHS). Here we report a case of near fatal fever, rash, and hepatitis secondary to dapsone.

Keyword :

Dapsone Hypersensitivity, Dapsone Syndrome, Leprosy, Multidrug Treatment