Abstract :
The main aim of this investigation is to develop fast disintegrating oral films of new moiety of coumarin by using
Pectin and synthetic polymers. The coumarin moiety loaded oral-dispersible films were formulated by using HPMC
, pectin, ethyl cellulose as film forming polymers. The selected polymers were natural and synthetic water soluble
polymers. Generally solvent casting method was used in the manufacture of the mouth dissolving films. The formula
which incorporates pectin ,HPMC , EC and also other varying ratio of solvents(DMSO, water, Ethanol) were used
in the formulation of Oro-dispersible films. Citric acid was used as a salivary stimulating agent. The prepared films
were subjected to the analysis of various evaluation tests such as weight variation, tensile strength, thickness,
surface pH, and drug content. The significant parameters such as disintegration and dissolution profiles also
studied in detail since the product was prepared for fast dissolving in the oral cavity. Based on all combinations of
formulation one ideal formulation i.e, F4 is selected which acts as promising tool for systemic delivery of new
moiety of coumarin.
Keyword :
FABRICATION AND EVALUATION OF FAST DISTINTEGRATING ORAL HYBRID FILMS OF NEW MOIETY OF COUMARIN