Abstract :
Introduction: Preeclampsia and eclampsia complicate 6-8% of pregnancies. It is a serious multisystem
disorder specific to pregnancy and is a global problem leading to adverse maternal and perinatal
complications. In the recent years monitoring of lactate dehydrogenase (LDH) levels is proposed as
prognostic in predicting preeclampsia complications.
Materials and Methods: This prospective comparative study was conducted in the Department of
Obstetrics and Gynaecology, Mysore Medical College and Research Institute. Total of 210 pregnant women
were studied. They were divided into groups of mild preeclampsia (n=60), severe preeclampsia (n=60),
eclampsia (n=30) and normotensive pregnant women (n=60) as control group. LDH levels were done in
study group and correlated with maternal and perinatal complications.
Results: LDH levels were significantly elevated in patients with preeclampsia and eclampsi a (F -statistics
value =43.4076, df = 3, P value < 0>
diastolic blood pressures correlated with high LDH (P
were significantly correlated with high LDH (P
Conclusion: Serum LDH values significantly correlate with severity and clinical outcome of preeclampsia
and eclampsia. Raised LDH levels suggest heightened risk developing maternal and perinatal
complications. LDH can be offered as prognostic tool to predict preeclampsia and eclampsia complications.
Keyword :
Maternal outcome, Perinatal outcome, Preeclampsia, Eclampsia, Lactate dehydrogenase.