Abstract :
Introduction: Meningiomas are mostly benign tumour and major prognostic factor for recurrence is
mostly dependent on the histopathological category, proliferation indices, grading and estrogen (ER) and
progesterone (PR) receptor status. The present study was undertaken to find ER, PR receptor in excised
specimen of meningioma and its correlation with Ki67 labelling index.
Materials and Methods: 75 cases of meningioma collected over period of 2 years was subjected to
Haematoxylin and Eosin staining for routine histopathological investigation and immunohistochemical
staining against PR, ER and Ki-67 by means of mouse monoclonal antibodies. Ki-67 labelling index
was determined and Histological grade, PR, ER receptor status was evaluated.
Results: The Mean Ki-67 LI was significantly higher in PR-negative versus PR-positive meningioma,
Grade II versus Grade I and males versus females. Whereas the PR positivity was significantly higher in
Grade I versus Grade II and females versus males. A strong converse relationship was established between
PR expression and Ki-67 LI.
Conclusions: As per the results it has been revealed that immnodetection of ki-67 LI and PR expressions
in meningiomas are the important indicators for assessing prognosis and recurrence rate in meningioms.
Keyword :
Meningiomas, Histopathology, Ki67, Progesterone, Estrogen, Haematoxylin, Eosin