Author :
Abhishek Bhuava, Akshaya N Shetti, Vinod Kharde, VK Badhe, Das Divekar
Volume :
3
Issue :
1
Abstract :
Introduction: Preanesthetic medication forms an integral part of anaesthetic management. Pharmacological and non-pharmacological techniques are tried to achieve anxiolysis and better hemodynamic stability. Clonidine is alpha 2 agonist and acts on central nervous sytem. It is adminstered in various route and oral route is one of them. This study has been designed to study the effect of oral clonidine on perioperative hemodynamics.
Aims: To evaluate beneficial effects of oral clonidine in attenuating the haemodynamic responses and comparing with placebo in patients undergoing surgeries under general anaesthesia.
Settings and Design: Randomized double blind study.
Methods and Material: Two hundred patients were enrolled in this study and studied for 2 years. Randomization was carried out. Four groups, including 50 patients per group were created. Group I (Placebo) received oral tablet ranitidine 150 mg, Group II C2, C3 and C4received oral clonidine 2 µg/kg, 3µg/kg and 4µg/kg body weight respectively. Sedation, anxiolysis and hemodynamic changes were recorded.
Statistical analysis used: The statistical significance for categorical variables was determined by chi-square test. For continuous variables two sample t-test was applied. For intra group comparison paired t- test and for inter group comparison unpaired t-test was used. Results were expressed as Mean ± SD (standard deviation). A P value < 0.05 was considered statistically significant.
Results: No statistically significant differences concerning demographic data between the groups of patients computed. A significant difference observed with respect to sedation and anxiolysis between all the four groups. The HR response between clonidine (2 µg/kg, 3µg/kg and 4µg/kg) and placebo was very significant at all times (p