Abstract :
Dyschromatosis Universalis Hereditaria (DUH) is an AD (autosomal dominant) genetic skin disorder, rarely sporadic and is characterized by a combination of different types of pigmented macules in a reticulate or mottled arrangement all over the body. DUH usually develops during childhood. It differs from other pigmentary disorders because the pigmentation changes are widespread, symmetric, and often affect the face, trunk, and limbs. It was previously believed that DUH resulted from an abnormal number of melanocytes, excessive melanosome production, or improper distribution of melanin within the epidermal melanin units. DUH treatment options are limited, as there are no proven therapies to reverse or prevent skin colour changes. Current management focuses on minimizing sun exposure, using sunscreen, and addressing cosmetic concerns. While DUH is primarily a cosmetic concern, the condition can cause psychological distress due to the visible nature of the lesions.
Keyword :
Dyschromatosis universalis hereditaria, Dyschromatosis symmetrica hereditaria or acropigmentation of dohi, Dyskeratosis congenita / Zinsser engman cole syndrome, Xeroderma pigmentosum, Generalized Dowling degos disease Or Reticulate pigmented anom