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Dissociation between vibration and joint position sensation in a case of metronidazole-induced reversible axonal polyneuropathy


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Article type :

Case Report

Author :

Rajarshi Chakraborty* , Ravi Uniyal, Harish Nigam, Ankit Khetan, Mohd Imran Khan, Swati Shakya

Volume :

11

Issue :

1

Abstract :

Axonal neuropathy is an important neuropathic entity with guarded prognosis globally. Metabolic, inflammatory, vasculitis, infections, drugs and toxins are common causes of axonal neuropathy. Metronidazole is a commonly used anti-anaerobic and anti-protozoal medication in tropical countries having diverse utility. The neurological manifestations of metronidazole toxicity is diverse. The sensation of joint position and vibration ascend via common pathway of dorsal column tract. However, certain diseases can affect selective modality of sensation in the form of dissociation between vibration and joint position sensation. In this case report, we discuss a person presenting with distal paresthesia and tried to explore the various treatable aetiologies of axonal sensorimotor polyneuropathy in a 45 year-old man. A proper history and clinical examination can guide to exclusion of various clinical aetiologies.

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