Article type :
Review Article
Author :
Sunil Palchaudhuri, Anubha Palchaudhuri, Biplab Chatterjee, Charu Jha
Volume :
1
Issue :
1
Abstract :
Alterations of penicillin binding proteins (PBP) by a series of point mutations in the pbp genes of Diplococcic Streptococcus chromosome (2300 Kb approx) are apparently responsible for antibiotic resistance crisis. In order to develop a preventive treatment, we should not forget that these patients, children and the elderly are not competent enough for immune response and therefore the available vaccines even polyvalent ones may not always be effective. Most recently, we have recognized that the bacterial reproduction and maturation are regulated by the two –component signaling system via diplococcic streptococcus cleavage. Thinning of cell wall by the growth in Xylitol eliminates cleavage and ideally fulfils our requirement for a low-cost preventive therapy to save human lives and their miseries from bacterial pneumonia, meningitis, otitis media and dental caries.