Abstract :
Introduction: Non protein Bound iron has the capacity to generate reactive oxygen species is called Free iron causing lipid peroxidation and protein oxidation. Free radicals have been implicated in the pathogenesis of diabetes mellitus. Hence the present study was conducted to compare serum levels of free iron, superoxide dismutase, malondialdehyde & glycated hemoglobin between type 2 diabetes mellitus with microvascular complications (retinopathy and nephropathy) and type 2 diabetes mellitus without complications.
Methods: Cross sectional observational study included total 121 subjects. 60 were healthy controls, 31 cases with type 2 diabetes mellitus without complications, 30 cases with microvascular complications (15 nephropathy and 15 retinopathy cases). Estimation of serum levels of free iron, superoxide dismutase, malondialdehyde, random plasma glucose, and HbA1c, were estimated by spectrophotometric method.
Results: Serum levels of random plasma glucose (
Keyword :
Free iron, superoxide dismutase, HbA1c, Malondialdehyde, Oxidative stress, Antioxidants, Type 2 diabetes mellitus, Retinopathy, Nephropathy.