Author :
Ngangbam Sonamani, Ghanshyam Das, Waseem Iqbal, Shobha B, Sunil Bhat
Volume :
2
Issue :
1
Abstract :
Objective: To evaluate the factors associated with conjugated hyperbilirubinemia and its contribution to outcome and prognosis of neonates with jaundice.
Design: A prospective and observational study.
Setting: Kamla Raja Hospital, G. R. Medical College, Gwalior (M.P.) for a period of 1 year.
Participants: Consecutive term and late preterm LBW neonates reporting with hyperbilirubinemia to the center were recruited in the study.
Method: Relevant history, clinical findings and appropriate laboratory investigations of the eligible cohort were obtained and the cohort was followed-up till discharge or final outcome to assess the risk, the time to and the rate of mortality(n=126).
Results: The median values of total, conjugated and unconjugated bilirubin in the cohort were 18.6 (IQR 7.2), 2.8 (IQR 2.1) and 15.3 (IQR 6.425) mg/dl respectively. These values were used to dichotomize the variables into high and low. A strong association was observed between perinatal hypoxic ischemia and conjugated hyperbilirubinemia (p=0.026, ?2=4.214, ?=0.144, odds ratio=3.886). Conjugated hyperbilirubinemia was found to be strongly associated with sepsis indicating the probable role of sepsis in conjugated hyperbilirubinemia (p