Abstract :
Introduction: Cardiovascular disease is the most common cause of death worldwide among which
coronary heart disease (CHD) is the main culprit. Conventionally the estimation of serum lipids like
cholesterol, triglycerides, LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) are used to assess the
risk of CHD. However, the inaccuracies in the correlation between serum lipid profile and CHD, led to the
development of better indicators. Among them the estimation of serum apolipoprotein is now increasingly
used for risk assessment of CHD. In HDL-C main protein component is Apolipoprotein A-I. Apo A-I and
HDL-C are protective; Apolipoprotein B (Apo B) and LDL-C are atherogenic. The current study is carried
out to evaluate and compare the efficacy of Apo B and Apo A-I level with LDL-C and HDL-C level as risk
factors of coronary heart disease.
Materials and Methods: Total 45 clinically diagnosed patients of coronary heart disease with age group
of 30-65 years and 45 age and sex matched healthy individuals were included in study. Their serum
levels of Apo A-I, Apo B, total cholesterol, HDL-C, LDL-C triglycerides and VLDL-C were measured
and compared between CHD patients and healthy controls.
Results: No significant difference was found in total cholesterol (TC), HDL cholesterol and LDL
cholesterol levels, only VLDL cholesterol was significantly higher in CHD patients compared to controls
(p < 0>
controls and the differences were highly significant (p < 0>
Conclusions: This study indicates ratio of Total Cholesterol to HDL-C and LDL-C to HDL-C can be
helpful in assessing risk of CHD while raised Apo B to Apo A-I ratio is highly suggestive risk factor for
CHD.
Keyword :
CHD, LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), Apolipoprotein A-I, Apolipoprotein B.