Abstract :
Introduction: Post operative nausea and vomiting (PONV) is a common complication after general
anaesthesia, specially post laparoscopic surgeries. This study compared efficacy of palonosetron with
ondansetron for prevention and management of PONV in patients undergoing laparoscopic gynaecological
surgeries.
Materials and Methods: 100 patients, undergoing laparoscopic gynaecological surgery were randomly
divided in 2 groups of 50 each. They received either ondansetron(4mg IV) or palonosetron (0.075mg IV)
before induction of general anaesthesia. They were monitored post operatively till 72 hours for episodes of
nausea, vomiting, overall PONV and adverse effects.
Result: The incidence of overall PONV was significantly less in patients who received palonosetron as
compared those who received ondansetron. Also, ondansetron group demonstrated higher use of rescue
anti-emetic drug as compared with palonosetron group. No significant difference was found in incidence
of adverse effects in both groups.
Conclusion: Palonosetron, having longer duration of action, is more effective in treating long term PONV
compared to ondansetron in patients undergoing laparoscopic gynaecological surgeries under general
anesthesia.
Keyword :
Palonosetron, Ondansetron, Post operative nausea vomiting, Laparoscopic gynaecological surgeries, Anti-emetic drugs.