Abstract :
Previous studies reported that Pulicaria somalensis (Asteraceae) and related members of this family have long been used in folk
medicines and because of its antioxidant activity, has an effective role in protection of biomarkers of cardiac and renal
dysfunction. The aim of the present study was to evaluate the protective effects of Pulicaria somalensis mthanolic extract (PSME)
on carbon tetrachloride (CCl4)-induced changes in cardio-and nephro-toxicity. For the cardio-protective activity, biochemical
parameters such as LDH, creatine kinase and albumin in serum, total protein, MDA and NP-SH levels in myocardial tissues
were estimated. For the evaluation of nephro-protective activity, biochemical parameters such as creatinine, urea, uric acid,
sodium, potassium and calcium in serum, total protein, MDA and NPSH levels in renal tissues were assesed. The results of the
present finding showed a significant (P
Keyword :
Pulicaria somalensis, cardioprotective, nephroprotective, Carbon tetrachloride, Histopathology