Abstract :
Introduction: Tinea corporis is a superficial dermatophytic infection of the glabrous skin surface of face, trunk and extremities that can be diagnosed by clinical examination, skin scrapings and skin punch biopsies. Histopathological evaluation with PAS stain aids in definitive diagnosis. Causative organisms are T.rubrum, T.mentagrophytes, T.concentricum, E.floccosum. Clinical presentations can be altered with use of various self-medicated applications and hence can pose diagnostic challenges.
bjectives: Objective of the current study is to elaborate the histomorphological changes in the skin biopsy of partially treated cases of tinea corporis. Histopathological features include epidermal changes and dermal inflammatory response.
Materials and Methods: This study is a cross-sectional study in a period of 2022-2023. A total of 100 skin biopsy cases were analysed from histologically confirmed PAS (periodic acid-Schiff) positive cases of partially treated tinea corporis.
Results: Most of the cases showed epidermal changes of spongiosis (91%) followed by orthokeratosis (85%). Other epidermal changes seen were parakeratosis (32%), Neutrophilic exocytosis (23%), Hyperkeratosis (9%) and microabscess (4%). Papillary dermis showed perivascular lymphocytic infiltrate (95%) with extravasated neutrophils (16%), extravasated RBCs (27%), eosinophils (21%) and perivascular edema (26%).
Conclusion: Local application of triple combination or steroid creams can alter the pattern in the lesion making diagnostic challenges both clinically and histopathologically. Histopathological evaluation of partially treated tinea corporis reveals presence of lamellated orthokeratosis with or without focal parakeratosis, acanthosis and spongiosis. In our study, Exocytosis of neutrophils, papillary dermal edema were noted only in few cases and lacks sandwich sign. This study, thus attempts to elaborate on subtle changes in histopathological features of partially treated Tinea corporis with unknown topical applications.
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