Abstract :
Introduction: Diabetes mellitus (DM) refers to a group of common metabolic disorders with abnormal
plasma glucose levels and disturbance in various metabolic pathways. Prostate specific antigen (PSA), a
glycoprotein secreted by prostatic cylindrical cells and under the strong influence of androgens. Aim of
the study was to compare serum PSA between diabetic and non-diabetic subjects and also correlate with
Glycated hemoglobin (HbA1c), fasting blood sugar (FBS) and post prandial blood sugar (PPBS) in diabetic
and non-diabetic subjects.
Materials and Methods: The present study was carried out in 85 diabetic subjects and 165 healthy
controls in tertiary care hospital Surat. All the subjects were males categorized in different age and
BMI and different duration of diabetes mellitus groups. Blood was collected and serum was analyzed
for various biochemical parameters, fasting blood sugar, post prandial blood sugar by ERBA XL-640 fully
auto analyzer, prostate specific antigen by e411 fully auto electrochemiluminescence (ECLIA) analyzer and
Glycated hemoglobin HbA1c by high pressure liquid chromatography (HPLC) principle based BIO-RAD
D10 analyzer by using whole blood. Student t test used to compare two groups and pearson correlation
coefficient (r value) used for correlation and p value, p
statistical significant used for statistical analysis.
Results and Discussion: A significant decrease (p
and HbA1c in the diabetic subjects compared to healthy controls was observed. Serum concentration of
prostate specific antigen was significantly low (0.53 0.23 ng/ml) (p
compared to healthy controls (0.84 0.60 ng/ml). The concentration of serum PSA was observed to be
significantly low (p
years duration.
Conclusion: Lower level of Prostate specific antigen was recorded in diabetic subjects compared to healthy
controls, which was due to low level of insulin like growth factor 1(IGF-1) in long term diabetes which is
attributed to decrease in insulin production. In diabetic patients there is a need of reduction of cut off value
of prostate specific antigen after study done with more number of subjects.
Keyword :
PSA, Diabetes, HbA1c.