Abstract :
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. About 10% of latent infections progress to active
disease which, if left untreated, kills about half of those infected. In immunocompetent individuals, exposure to M tuberculosis usually results in a
latent/dormant infection. Only about 5% of these individuals later show evidence of clinical disease.The three key drugs, isoniazid, pyrazinamide
and rifampicin, used in the regimen are said to be potentially hepatotoxic and may lead to drug-associated hepatitis. The clinical relevance of
therapeutic monitoring of serum rifampicin and isoniazid concentrations in managing antituberculosis drug-associated toxicity is still being
explored.So as to identify the potential side effects of those drugs a Prospective,observational study was carried out in Krishna Institute of
Medical Sciences (KIMS) hospital at the outpatient department (OPD) of Pulmonology among forty nine patients. Prescriptions, OPD cards and
measurement of required parameters were the sources of data. In this study inclusion criteria involves patients of age groups 18-80 years
including only outpatients, Patient with/without co-morbidities.The Exclusion criteria involves Patients not willing to give consent, Pregnant and
lactating women. Out of total number of patients Males were 21 whereas Females were 28.According to Study conducted it was reported that
prevalence and proportion of side effects was different among Men and Women. In Females 22.81% were reported with side effects of vomiting,
22.81% with diarrhea 17.54% with joint pain ,10.53% with skin rash, 22.81% with headache, and 3.51% were reported with Hepatotoxicity
.Whereas in Males 25% reported to experience vomiting, 25% with diarrhea, 15% with headache,15% with joint pain and skin rashes and
merely 5% were reported with side effect of hepatotoxicity. Thus this study revealed that the Hepatotoxicity appears to be more prevalent in Male
subjects than Females which may give a base to the further studies to address a question why Male candidates are prone to hepatotoxicity than
their counter gender.
Keywords: Hepatotoxicity, Anti-tuberculosis drugs, hepatotoxicity,Vomiting, Diarrhoea
Keyword :
Hepatotoxicity, Anti-tuberculosis drugs, hepatotoxicity,Vomiting, Diarrhoea