Abstract :
The co-occurrence of leucine-rich glioma-inactivated 1 (LGI1) and N-Methyl-D-aspartate receptor (NMDAR) antibodies in paired serum and cerebrospinal fluid (CSF) samples in limbic encephalitis is a rare occurrence and its clinical presentation is not known. We report a case of a patient with limbic encephalitis presenting the symptoms of both LGI1 and NMDAR components. This case highlights the significance of a thorough diagnostic evaluation in suspected autoimmune dementia in elderly. Autoimmune antibody panels testing in suspected limbic encephalitis may help in identifying treatable dementias. LGI1 and NMDAR case reports have been published in various journals, the concurrent occurrence of both conditions in a single patient has hardly been published before.
Keyword :
Leucine-rich glioma-inactivated 1(LGI1), N-methyl-D-aspartate receptor (NMDAR), Limbic Encephalitis, Autoimmune encephalitis, Double-positive encephalitis