Abstract :
Newborn or neonate denotes to an infant in the first few days after birth. They are not small children when it comes to medicinal use and formulation development. Neonates include term, post-term and preterm babies. The neonatal period for preterm newborn infants is defined as the day of birth through to the expected date of delivery plus 27 days [1]. The majority of drugs used in sick newborns receiving intensive care are unlicensed and off-label, exposing infants to a greater risk of adverse drug reactions (ADRs). This study is extremely important due to the presence of a variety of drug information sources if used together lead to medication errors. From this point of view, this approach is suggested to eliminate or minimize these varieties. Where the most important challenges in neonatal intensive care unit (NICU) is proper and correct calculations and administration. Drug-related events in a hospital setting are the highest cause of recorded errors such as in the USA and UK [2]. However, there are a wide range of potential sources of drug errors including documentation, calculation, preparation and administration [3]. Now, babies commonly receive off-label drugs, at dosages extrapolated from children or adults. Besides the lack of labelling, inappropriate formulations, polypharmacy, immature organ function and multiple illnesses further raise the risk for ADRs in neonates [2].
Keyword :
Administration, dosage form, formulation, medication error, newborn, neonates, NICU