Abstract :
Wegener's Granulomatosis (WG) which is otherwise called as Granulomatosis with polyangiitis (GPA) is an
uncommon multi system autoimmune diseases, which is exceptionally connected with Anti-Neutrophil Cytoplasmic
Antibodies (ANCA). Wegner's Granulomatosis is a complex multisystem vasculitic disease characterized by necrotizing
small arteries and veins of unknown reason. In WG remission can be accomplished by regular immunosuppressive
treatment. The causes of WG includes infectious and environmental triggers, drug induced ANCA-associated vasculitis
(AAV) and also genetic factors. Staphylococcus aureus is a common micro-organism implicated in the pathogenesis of
WG and the repeating, relapsing nature of the disease might be connected to steady colonization of nasal sections with
this organism. Staphylococcus aureus creates super antigens which activate B and T Cells, and through a procedure of
sub-atomic mimicry Staphylococcus aureus can likewise actuate AAV. The symptoms of WG include fevers,
conjunctivitis, rhinitis, cough, myalgia, and necrosis. The diagnostic tests include ANCA testing, chest radiography, CT
scanning, abnormal kidney function tests etc. Wegener’s granulomatosis affects various organs such as heart, eye,
kidneys and lungs. Treatment of WG is considered to have two stages: induction, where active infection is put into
remission; and support, where remission is managed. The backbone of treatment for WG is a mix of corticosteroids and
cytotoxic agents.
Keywords: Wegener’s granulomatosis, vasculitis, Anti-Neutrophil Cytoplasmic Antibodies, cyclophosphamide.
Keyword :
Wegener's granulomatosis, vasculitis, Anti-Neutrophil Cytoplasmic Antibodies, cyclophosphamide.