Abstract :
Now a day most of the patients on long term therapy of glucocorticoid become insensitive to corticosteroids and addition of vitamin D to such patients may enhance to response to corticosteroids. Therefore, we investigated anti-inflammatory activity of vitamin D in presence of glucocorticoids receptor antagonist; mifepristone, to assess whether, vitamin D acts as dependent or independently from glucocorticoids receptor. Wistar albino rats were sensitized with ovalbumin (OVA) and, upon OVA challenge, developed
airway eosinophilia and neutrophilia. Administration of dextamethasone, vitamin D and combination of dextamethasone vitamin D, and dextamethasone vitamin D mifepristone significantly (P
Keyword :
Asthma, Vitamin D, Mifepristone.