Abstract :
Background: Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and cardiovascular comorbidities that influence perioperative and critical care outcomes. Urinary microalbumin and the albumin-creatinine ratio (UACR) reflect endothelial dysfunction and microvascular disease. We evaluated their association with COPD severity and considered their potential utility in perioperative risk assessment.Materials and Methods: In this observational study, stable COPD patients were stratified by Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Spot urine samples were collected and analyzed for albumin and creatinine, and the UACR was calculated. We compared UACR across COPD severity groups and examined correlations with lung function and oxygenation indices.Results: Consistent with prior reports, patients with advanced COPD had significantly higher urine microalbumin levels and UACR than those with mild disease. UACR increased progressively from GOLD stage I to IV. In our cohort, higher UACR was inversely correlated with FEV? and PaO? (p
Keyword :
Chronic obstructive pulmonary disease, Microalbuminuria, Albumin-creatinine ratio, Endothelial dysfunction, Systemic inflammation, Perioperative risk, Cardiovascular comorbidity.