Abstract :
Background: Neurodegenerative disorders such as Parkinson’s and Huntington’s diseases are influenced by complex interactions between genetic predispositions and environmental factors. Identifying genetic markers and understanding how environmental exposures impact these diseases are critical for developing effective therapeutic strategies. Objective: This study aimed to analyze the genetic risk factors and environmental contributions to Parkinson’s and Huntington’s diseases, with a focus on identifying common genetic markers and assessing the impact of environmental exposures. Methods: Twelve patients diagnosed with Parkinson's or Huntington's disease were selected for genetic and environmental factor analysis. Genetic predispositions were examined through DNA sequencing targeting known risk genes such as LRRK2 for Parkinson’s and HTT for Huntington’s. Environmental exposures were assessed through patient surveys. The study also integrated advanced bioinformatics tools for data analysis, but lacked a longitudinal follow-up to track progression and variability of the diseases over time. Results: The impact of genetic mutations on disease predisposition was significant, with LRRK2 and HTT mutations scoring 4 and 5 respectively on an impact scale. Environmental factors showed a moderate influence, with pesticide exposure in Parkinson’s and heavy metal exposure in Huntington’s scoring 2 and 1, respectively. Statistical analysis revealed a strong association between genetic factors and disease manifestation with p-values
Keyword :
Keywords: Bioinformatics, DNA sequencing, Environmental exposure, Genetic markers, Huntington’s disease, LRRK2, Neurodegenerative diseases, Parkinson’s disease, HTT