Volume :
2
Issue :
2
Abstract :
The transdermal patch has become a proven technology which offers a variety of significant clinical benefits over other dosage forms. Transdermal drug delivery system has emerged a new era in controlled release of the drug, maintains steady blood level profiles, reducing systemic side effects, avoiding hepatic first pass metabolism and improved efficacy. TDDS is an excellent mode of delivery which has been explored extensively over the last 25 years with therapeutic success and is suited ideally for the diseases which require chronic treatment. The transdermal route of dug delivery has attracted many researchers due to its biomedical applications, but however, excellent impervious nature of skin which acts as a barrier is the greatest challenge that has to be overcome for successful delivery of drug molecules to the systemic circulation. To achieve this, numerous or several approaches are used such as use of prodrugs/lipophilic moiety, permeation enhancers, physical approaches like iontophoresis, electroporation and sonophoresis, stripping of stratum corneum, hydration of stratum corneum, chemical approaches and biological approaches. This article deals with basic components of TDDS, different approaches and methods of preparation of TDDS, and advanced techniques to facilitate the permeation of drug molecules through the skin.