Abstract :
Background: Tracheal extubation evokes various degrees of disturbances in the autonomic nervous system
in the form of tachycardia, hypertension which can cause deleterious consequences in susceptible patients.
Hence this study was conducted between iv Dexmedetomidine and iv Labetalol to compare their
effectiveness in the suppression of haemodynamic response to tracheal extubation.
Materials and Methods: 60 participants aged between 18-55 yrs belonging to ASA 1 or 2 were randomly
allocated into 2 groups. Group Dd received injection Dexmedetomidine 0.6mcg/kg iv and Group Ll
received injection Labetalol 0.25mg/kg body weight. Heart rate, systolic and diastolic blood pressure were
recorded at baseline, 2,5,8 minutes after drug infusion, at extubation and 1,3,5,8,10 and 15 minutes post
extubation.
Results: Group Dd showed a better decrease in heart rate, systolic and diastolic blood pressure at
extubation, and 15 minutes post extubation compared to Group Ll.
Conclusion: Injection Dexmedetomidine 0.6mg/kg showed a better attenuation of sympathoadrenal
response to extubation compared to injection Labetalol 0.25mg/kg.
Keyword :
Dexmedetomidine, Labetalol, Extubation.