Abstract :
Aims: Assessment of the degree of attenuation of pressor response to tracheal manipulation, with Esmolol
and Dexmedetomidine as premedication, in patients posted for elective laparoscopic cholecystectomy.
Settings and Design: The current randomised prospective study was designed and sixty patients of
American Society of Anaesthesiologist class I and II undergoing laparoscopic cholecystectomy were
included in the study.
Methods and Materials: Sixty patients were randomised into two groups, Group E and Group D. Patients
of group E (n=30) received Inj. Esmolol (0.50 mg/kg) in 10 ml normal saline two minutes before intubation
and patients of group D (n = 30) received Inj. Dexmedetomidine (0.5mg/kg) in 10 ml normal saline over
10 minutes prior to intubation. In both the groups, at baseline and at various time intervals after study drug
administration, hemodynamic parameters were recorded.
Statistical analysis: SPSS software version 15.0 is used for statistical analysis. The values were
represented as Mean SD. Student’s t-test was used for analysis of various parameters.
Results: The demographic data and initial baseline hemodynamics were statistically similar. The
sympathetic response to tracheal manipulation was significantly attenuated (p but dexmedetomidine blunts the pressor response more effectively.
Conclusion: Among dexmedetomidine and esmolol, dexmedetomidine seem to be a promising drug to
control the pressor response to tracheal manipulation.
Keyword :
Esmolol, Laparoscopic cholecystectomy, Dexmedetomidine.