Abstract :
Background: People spend about one third of their life in sleeping. The various sedative and hypnotic
drugs currently used have various adverse drug reactions. In 1977 Budhiraja et al have done insufficient
work on the Withania coagulans – a susceptible species that is not found plentiful in the world. Therefore,
it was critical to discover the Central Nervous System (CNS) depressant activities of alcoholic extract of
Withania coagulans fruits in Swiss albino mice by means of actophotometer.
Materials and Methods: The spontaneous locomotor action was assessed by means of the actophotometer.
The CNS depressant medications reduce the exploratory action in rodent as they weaken the motor
coordination so that rodent is stationary for a considerable time. Thus, there is fewer interruptions to the
rays of light. This spontaneous locomotor movement duration is statistically compared with the control,
standard and the test drugs.
Results: There was statistically highly significant (p-value < 0>
alcoholic excerpt of Withania coagulans fruits with spontaneous locomotor action in Swiss albino mice
on the photoactometer.
Conclusion: The alcoholic excerpt of Withania coagulans fruits established the CNS depressant action in
Swiss albino mice by photoactometer.
Keyword :
CNS depressant; Photoactometer; Swiss albino mice (SAM); Withania coagulans.