Abstract :
The Objective is to review the mechanisms by which RBCs and hemoglobin contribute to arterial disease and atherosclerosis and to explore the implications of these mechanisms for disease progression and potential therapeutic interventions. Red blood cells (RBCs) and hemoglobin influence arterial health by affecting blood viscosity and frictional forces on arterial walls. In atherosclerosis, RBC collisions release cytotoxic heme-Fe , promoting cell death and contributing to disease progression. This local hemolysis is also linked to oxidation in abdominal aortic aneurysm. The regulation of blood viscosity by RBCs is crucial for maintaining regional metabolic requirements and arterial function. Atherosclerosis is a leading cause of cardiovascular diseases, influenced by factors such as hypertension, high cholesterol, smoking, and diabetes. Emerging evidence suggests that red blood cells (RBCs) and hemoglobin play significant roles in the disease's pathogenesis. A comprehensive literature review was conducted, focusing on the interaction between RBCs, hemoglobin, and the arterial wall, including their roles in oxidative stress, inflammation, blood viscosity, and plaque formation.
Keyword :
RBC, Hemoglobin, arterial wall, Atherosclerosis, Clotting etc
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